Pdf oxidative destruction of picric acid in aqueous media. Picric acid is an organic compound with the formula o2n3c6h2oh. Remove from source of exposure and get immediate medical attention for any breathing difficulty. Persistence and degradability picric acid, saturated. Salts with ammonia, amines and complexes with hydrocarbons are less sensitive kirkothmer, 1965, vol.
Picric acid is an organic compound with the formula o 2 n 3 c 6 h 2 oh. We regularly produce chemical solutions to specifications designed by government and regulatory bodies, commercial and trade associations, and the specific needs of individual users and businesses. Avantik 19 chapin road building c pine brook, nj 07058 t. Jul 29, 2011 picric acid 2,4,6trinitrophenol, no23c6h2oh is widely used in metallography labs for the common steel etchants known as picral, a 4% solution in ethanol, vilellas reagent, 1 g picric acid and 5 ml hcl and 100 ml ethanol, and alkaline sodium picrate 2 g picric acid, 20 g naoh, 100 ml water for coloring m3c and m6c carbides, as well as several other formulations. The dry compound can explode if shocked or exposed to heat.
It plays a role in how your page is seen by search engine crawlers, and how it appears in serps. Recommended use and restrictions on use general laboratory reagent 1. Picric acid safety introduction picric acid 2,4,6trinitrophenol is an organic compound that is commonly used in organic chemistry and as a fixative and stain in histology. See section 2 and section 9 applicable information. For manufacturing, processing, laboratory or repacking use only.
Well, lets look at the history of the use of picric acid and see what can be done to avoid those types of situations. A meta description is an html tag in the html code of your website, which allows you to customize a section of text that describes the page itself. Details of the supplier of the safety data sheet fisher. It is used as a high explosive, an oxidant in rocket fuels, in matches and leather processing, in dyes, as a laboratory reagent for serum creatinine analysis in humans and experimental animals, other laboratory uses, metal etching, batteries, as a textile mordant, in manufacture of colored glass, and in the production of picramic acid and chloropicrin. Picric acid formaldehyde paf fixative has been compared to other fixatives commonly employed in electron microscopy in order to check its ability to be used in immunoferritin studies. Picric acid should be disposed as a hazardous waste within 2 years of initial receipt.
Acetone is not expected to be toxic to fish but picric acid is. It is primarily used as a staining reagent and in synthesis reactions. In subsequent steps, the nitronium ion attacks at the 2 and 4positions, displacing the sulfonic acid groups and forming 2,4,6trinitrophenol picric acid. The first product is probably 6nitrophenol2,4disulfonic acid. Aldrich 197378 page1 of 8 sigmaaldrich safety data sheet according to regulation ec no. Guidance document safe handling of picric acid this is a brief summary. It is no longer used as an explosive because of this type of reaction. Page 1 of 2 picric acid university of michiganflint. Anti acid sensitive ion channel 3 antibody, 285304 of extracellular domain of rat asic3. It has a role as an explosive, an antiseptic drug and a fixative. Picric acid is a highpowered explosive when allowed to dehydrate.
Relevant identified uses of the substance or mixture and uses advised. Picric acid may detonate if allowed to dry completely. Chemical product and company identification product name. Picric acid 2,4,6 trinitrophenol is frequently found in forensic laboratories for use in the christmas tree stain 1. As a highly nitrated compound, picric acid is highly explosive like tnt. Cdc niosh pocket guide to chemical hazards picric acid.
Picric acid no no none section xii ecological information environmental fate. Additionally, picric acid reacts vigorously with a variety of materials and is toxic to humans through all routes of entry 1. Maintain eyewash fountain and quickdrench facilities in work areas. Check with your local waste authorities recommended disposal methods. Normally, water is added to picric acid, otherwise the dry material is a touch sensitive explosive. Sufficiently pure samples of picric acid have the same order of stability as tnt chem. Safety data sheet 116920 picric acid moistened with. Picric acid definition is a toxic yellow crystalline phenol derivative c6h3n3o7 structurally similar to tnt and used especially as a high explosive and as a dye or mordant.
Before using any chemical, read the appropriate material safety data sheet msds. Phe publications gateway number 2014790 pdf, 159kb, 3 pages this file may not be suitable for users of assistive technology. Identification of the substancemixture and of the companyundertaking 1. Aspiration of acetone into the lungs may produce death. Picric acid trinitrophenol or 2,4,6 trinitrophenol explosion hazard when dry cas number 88891 date occurred 23rd may 2007 what happened a disposal request was received for a 500 gram jar of picric acid that had dried out. The moist picric acid was dehydrated before testing in accordance with directions described under the heading of section 9. Industrially, picric acid is especially hazardous because it is volatile and slowly sublimes even at room. Interaction of picric acid with sodium hydroxide in water.
Picric acid acetone solution page 5 health 2 fire hazard 3 reactivity 2 specifichazard health 2 3 2 health flammability physical hazard personal protection 16. Picric acid, when in contact with metals, can form sensitive metal picrates. A shockinsensitive explosive compound that forms shocksensitive explosive salts with metals such as lead is too unwieldy for most usual applications. Hazardous decomposition products formed under fire conditions carbon oxides, nitrogen oxides nox. Picric acid hazards attorney general of california. Information on picric acid stanford environmental health. The considerations for marketing and transportation of hazardous chemicals. Material safety data sheet west liberty university. Read the full msds for more details before handling. For safety transportation, 30% water or more is usually added. Picric acid definition of picric acid by merriamwebster. Bombs, mines and grenades were coated with tin or ashpatim to prevent the picric acid from contacting the metallic shell 8. It must be kept wet with water usually 30% or more because the dry solid is explosive. Download any file posted by another user of a community feature that you know, or reasonably should know, cannot be legally distributed in such manner or that you.
Abc of safety in the biological sciences picric acid. From the results obtained paf seems to offer very good preservation of the tissue fine structure together with satisfactory detection of immune reactions at. Like other highly nitrated organic compounds, picric acid is an explosive, hence its primary use. Safety data sheet according to federal register vol. Picric acid, saturated safety data sheet according to federal register vol. Our product line consists of chemical solutions prepared to exact quality standards and certified for use in laboratories and production processes. Safety data sheet 116920 picric acid moistened with 30% water. Picric acid 2,4,6 trinitrophenol is frequently found in forensic laboratories for use in the christmas tree stain 1 and for urine detection 2.
Eye contact can result in corneal damage or blindness. Picric acid is in the same family of nitroaromatic explosives as trinitrotoluene tnt. Read, download and publish picric acid magazines, ebooks for free at. Several catastrophic events involving picric acid have occurred. Picric acid, crystal, reagent, acs, also known as 2,4,6trinitrophenol or tnp. This chapter summarizes the current knowledge of the potential impacts of picric acid on wildlife, emphasizing threshold doses for the onset of toxicological effects, as described in reports of experimental studies of the compound. C6h3n3o7 finoric, etymologically derived from our business line of fine inorganic, organic and industrial chemicals, is the internationally preferred source for chemicals. Picric acid is a cnitro compound comprising phenol having three nitro substtituents at the 2, 4 and 6positions. Picric acid hazards office of the attorney general. Picric acid material safety data sheet cas no 88891. Picric acid can be detonated by extreme heat, a blasting cap, or an electric charge. Picric acid solution, saturated, for aoac method 920. Potential hazards the most serious hazard associateddamage. Oxidative destruction of picric acid in aqueous media by fentons reagent article pdf available in environmental engineering science 262.
Preparation of picric acid chemistry stack exchange. Picric acid, 2,4,6trinitromcresol, 3azido2,4,6trinitrophenol, styphnic acid, 2,4,6trinitro1,3,5benzenetriol, and their salts were. Picric acid safety guidelines concordia university. Msds of picric acid and ethidium bromide slideshare. It derives from a 1,3,5trinitrobenzene and a phenol. Picric acid understanding specific chemicals hazard. Picric acid acetone solution page 4 mobility in the soil. Picric acid pa, 2,4,6trinitrophenol is a polynitrated aromatic acid. Contact with metallic zinc or lead can cause detonation. The salts formed with ammonia and amines, and the molecular complexes with aromatic hydrocarbons, etc, are in general not so sensitive. It is a yellow crystalline solid and one of the most acidic phenols.
Make sure that any picric acid disposed of still has some water content. Picric acid page 4 of incident management physicochemical properties cas number 88891 molecular weight 229. Section xiii disposal considerations local governments may restrict the amounts of picric acid that may be flushed down the drain. Picric acid understanding specific chemicals hazard prevor. Due to its relatively low solubility it is commonly found as a saturated solution or slurry in.
Identification of the substancepreparation and of the companyundertaking identification of the product catalogue no. Pharmacopoeia eu pharmacopoeia reagents ph eur ref num. The complexes with aromatic hydrocarbons, etc, are in general not so sensitive the frictionsensitive calcium salt. Nowadays, picric acid has many uses including its use as a component of analytical reagents for testing blood and urine. Details of the supplier of the safety data sheet fisher scientific 300 industry drive.
Picric acidformaldehyde fixation for immunoferritin studies. Picric acid sds msds sheet, suppliers and manufacturers represantative cas no 88891, einecs ec number xxxxxxx, molecular weight. Central drug house p ltd 728 vardaan house new delhi2 india. However, as a strong acid, picric acid attacks common metals except tin and aluminum creating explosive salts, which are shocksensitive. The name picric comes from the greek pikros, meaning bitter, reflecting its bitter taste.
Picric acid material safety data sheet cas no 88891 sdsmsds. The acid has therefore proved to be a versatile multipurpose compound. Contact ehs for disposal for wet solutions of picric acid only. Burns if ignited by a flame and continues to burns quietly if the quantity is small or, if large, is thinly spread over an area. Picric acid 2,4,6trinitrophenol is a highly explosive compound most commonly used in military applications. Read, download and publish picric acid magazines, ebooks. Takashi kotoyori, in industrial safety series, 2005. Information of picric acid is the chemical compound formally called 2,4,6trinitrophenol. This yellow crystalline solid is one of the most acidic phenols and is vinylogous to nitric acid. Disposal considerations recommended disposal containers.
Contain if possible, prevent runoff into drains and sewers. Do not dispose of in drains, check with your local waste authorities. Country limit value ppm mgm3 picric acid moistened with 30% water 88891 united kingdom 1 eight hours 0,1 short term 0,3. Material safety data sheet picric acid, saturated 3 lined metal and label for disposal. Picric acid reacts with copper, lead and zinc to form compounds that are sensitive to mechanical shock.
Chemical and hazardous materials safety the university of texas. Material safety data sheet picric acid msds section 1. Picric acid sds msds sheet, material safety data sheet. Picric acid, wet, with not less than 10% water undergoes vigorous reactions with both oxidizing or reducing agents. Pdf oxidative destruction of picric acid in aqueous media by. Hazardous substances data bank, national library of medicine. Picric acid forms salts with many metals some of which are rather sensitive nickel, copper, etc. Add the material, slowly, while stirring, to 30 times its weight of a solution prepared by dissolving 1 part sodium sulphide in 6 parts water. Picric acid must be stored under a layer of liquid, as picric crystals are.